Leukotriene E4 elicits respiratory epithelial cell mucin release through the G-protein-coupled receptor, GPR99
Proc Natl Acad Sci U S A. 2016 May 31;113(22):6242-7. doi: 10.1073/pnas.1605957113. Epub 2016 May 16. ABSTRACT Cysteinyl leukotrienes (cysLTs), leukotriene C4 (LTC4), LTD4, and
Group V secretory phospholipase A2 modulates phagosome maturation and regulates the innate immune response against Candida albicans
J Immunol. 2009 Apr 15;182(8):4891-8. doi: 10.4049/jimmunol.0803776. ABSTRACT Phospholipase A(2) (PLA(2)) hydrolyzes the sn-2 position of cell membrane phospholipids to release fatty acids and lysophospholipids.
Affinity maturation and light-chain-mediated paratope diversification anticipates viral evolution
Cell Rep. 2025 Dec 30;45(1):116800. doi: 10.1016/j.celrep.2025.116800. Online ahead of print. ABSTRACT A key goal of vaccinology is to train the immune system to combat
Group V secretory phospholipase A2 is involved in macrophage activation and is sufficient for macrophage effector functions in allergic pulmonary inflammation
J Immunol. 2013 Jun 15;190(12):5927-38. doi: 10.4049/jimmunol.1203202. Epub 2013 May 6. ABSTRACT We reported that Pla2g5-null mice lacking group V secretory phospholipase A2 (gV-sPLA2) showed
Heterogeneous bone-marrow stromal progenitors drive myelofibrosis via a druggable alarmin axis
Cell Stem Cell. 2021 Apr 1;28(4):637-652.e8. doi: 10.1016/j.stem.2020.11.004. Epub 2020 Dec 9. ABSTRACT Functional contributions of individual cellular components of the bone-marrow microenvironment to myelofibrosis
Clonotype-enriched somatic hypermutations drive affinity maturation of a public human antibody targeting an occluded sarbecovirus epitope
Cell Rep. 2025 Aug 6:116122. doi: 10.1016/j.celrep.2025.116122. Online ahead of print. ABSTRACT Investigating public antibodies that recognize conserved epitopes is critical for vaccine development. Identifying