Effect of Lower Tidal Volume Ventilation Facilitated by Extracorporeal Carbon Dioxide Removal vs Standard Care Ventilation on 90-Day Mortality in Patients With Acute Hypoxemic Respiratory Failure: The REST Randomized Clinical Trial
JAMA. 2021 Sep 21;326(11):1013-1023. doi: 10.1001/jama.2021.13374. ABSTRACT IMPORTANCE: In patients who require mechanical ventilation for acute hypoxemic respiratory failure, further reduction in tidal volumes, compared
SARS-CoV-2 infects the human kidney and drives fibrosis in kidney organoids
Cell Stem Cell. 2021 Dec 25:S1934-5909(21)00520-8. doi: 10.1016/j.stem.2021.12.010. Online ahead of print. ABSTRACT Kidney failure is frequently observed during and after COVID-19, but it remains
The purinergic G protein-coupled receptor 6 inhibits effector T cell activation in allergic pulmonary inflammation
J Immunol. 2011 Aug 1;187(3):1486-95. doi: 10.4049/jimmunol.1003669. Epub 2011 Jul 1. ABSTRACT We show that the P2Y(6) receptor, a purinergic G protein-coupled receptor with a
SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues
Cell. 2020 May 28;181(5):1016-1035.e19. doi: 10.1016/j.cell.2020.04.035. Epub 2020 Apr 27. ABSTRACT There is pressing urgency to understand the pathogenesis of the severe acute respiratory syndrome
KVD900, an oral on-demand treatment for hereditary angioedema: Phase 1 study results
J Allergy Clin Immunol. 2022 Jun;149(6):2034-2042. doi: 10.1016/j.jaci.2021.10.038. Epub 2022 Jan 24. ABSTRACT BACKGROUND: Attacks of hereditary angioedema are attributed to excessive plasma kallikrein (PKa)
Mouse mast cell proteases 4 and 5 mediate epidermal injury through disruption of tight junctions
J Immunol. 2014 Mar 15;192(6):2812-20. doi: 10.4049/jimmunol.1301794. Epub 2014 Feb 12. ABSTRACT We previously established a mast cell (MC)-dependent thermal injury model in mice with