Secretory phospholipases A2 activate selective functions in human eosinophils
J Immunol. 2003 Mar 15;170(6):3279-88. doi: 10.4049/jimmunol.170.6.3279. ABSTRACT Secretory phospholipases A(2) (sPLA(2)s) are released in large amounts in the blood of patients with systemic inflammatory
Allergic inflammatory memory in human respiratory epithelial progenitor cells
Nature. 2018 Aug;560(7720):649-654. doi: 10.1038/s41586-018-0449-8. Epub 2018 Aug 22. ABSTRACT Barrier tissue dysfunction is a fundamental feature of chronic human inflammatory diseases1. Specialized subsets of
An adjuvant strategy enabled by modulation of the physical properties of microbial ligands expands antigen immunogenicity
Cell. 2022 Feb 2:S0092-8674(22)00067-8. doi: 10.1016/j.cell.2022.01.009. Online ahead of print. ABSTRACT Activation of the innate immune system via pattern recognition receptors (PRRs) is key to
Induced loss of Syk in human basophils by non-IgE-dependent stimuli
J Immunol. 2008 Mar 15;180(6):4208-17. doi: 10.4049/jimmunol.180.6.4208. ABSTRACT In the general population, Syk expression in human basophils is highly variable and correlates well with the
Mouse mast cell proteases 4 and 5 mediate epidermal injury through disruption of tight junctions
J Immunol. 2014 Mar 15;192(6):2812-20. doi: 10.4049/jimmunol.1301794. Epub 2014 Feb 12. ABSTRACT We previously established a mast cell (MC)-dependent thermal injury model in mice with
Efficacy and safety of dupilumab in patients with uncontrolled severe CRSwNP and a clinical diagnosis of NSAID-ERD: Results from two randomized placebo-controlled phase 3 trials
Allergy. 2021 Aug 30. doi: 10.1111/all.15067. Online ahead of print. ABSTRACT BACKGROUND: About one-tenth of patients with difficult-to-treat chronic rhinosinusitis with nasal polyps (CRSwNP) have