Research within the Vinik Center spans from basic immunobiology to disease pathogenesis and population health, and includes an emphasis in the following areas:
immune function of lipid mediators
innate immunity and inflammation
lymphocyte biology
immunometabolism
mast cell biology
immunoglobulin generation and signaling
microbiome research and immunocyte development
genomics and metabolomics of asthma and chronic inflammatory disease
clinical trials in asthma, aspirin-exacerbated respiratory disease, chronic sinusitis
clinical trials in mast cell disorders
population studies in asthma, food allergy, and drug allergy
Select Publications
Machine learning–derived genetic risk scores identify IL21 as a predictor of response to omalizumab and dupilumab in asthma
Tuft cells shape airway remodeling by eliciting OXGR1- and SOX9-dependent stem cell programs
Mast cell-specific CysLT2 receptor signaling inhibits cysteinyl leukotriene-dependent mast cell activation and type 2 allergic lung inflammation
Avapritinib achieves long-term disease control with favorable safety in patients with indolent systemic mastocytosis over 3 years
Beyond type 2 inflammation: An innate–myeloid axis is linked to recurrence of chronic rhinosinusitis with nasal polyps
Human intraepithelial mast cell differentiation and effector function are directed by TGF-β signaling
Management of patients with comorbid asthma and obesity: A large language model evaluation of clinical documentation
Rilzabrutinib for patients with moderate-to-severe asthma with uncontrolled symptoms: a double-blind, placebo-controlled, phase 2 study
Affinity maturation and light-chain-mediated paratope diversification anticipates viral evolution
Additional Information
For further Information please see links to our Research Faculty, Pre- and Post-doctoral Research Training Opportunities, Current Research Fellows, and Allergy and Immunology Fellowship.