Research

Research within the Vinik Center spans from basic immunobiology to disease pathogenesis and population health, and includes an emphasis in the following areas:

immune function of lipid mediators

innate immunity and inflammation

lymphocyte biology

immunometabolism

mast cell biology

immunoglobulin generation and signaling

microbiome research and immunocyte development

genomics and metabolomics of asthma and chronic inflammatory disease

clinical trials in asthma, aspirin-exacerbated respiratory disease, chronic sinusitis

clinical trials in mast cell disorders

population studies in asthma, food allergy, and drug allergy

Select Publications

Avapritinib versus Placebo in Indolent Systemic Mastocytosis

Gotlib J, Castells M, Elberink HO, Siebenhaar F, Hartmann K, Broesby-Olsen S, George TI, Panse J, Alvarez-Twose I, Radia DH, Tashi T, Bulai Livideanu C, Sabato V, Heaney M, Van Daele P, Cerquozzi S, Dybedal I, Reiter A, Pongdee T, Barete S, Ustun C, Schwartz L, Ward BR, Schafhausen P, Vadas P, Bose P, DeAngelo DJ, Rein L, Vachhani P, Triggiani M, Bonadonna P, Rafferty M, Butt NM, Oh ST, Wortmann F, Ungerstedt J, Guilarte M, Taparia M, Kuykendall AT, Arana Yi C, Ogbogu P, Gaudy-Marqueste C, Mattsson M, Shomali W, Giannetti MP, Bidollari I, Lin HM, Sulllivan E, Mar B, Scherber R, Roche M, Akin C, Maurer M

Association of GLP-1 Receptor Agonists with Chronic Obstructive Pulmonary Disease Exacerbations among Patients with Type 2 Diabetes

Foer D, Strasser ZH, Cui J, Cahill KN, Boyce JA, Murphy SN, Karlson EW. Association of GLP-1 Receptor Agonists with Chronic Obstructive Pulmonary Disease Exacerbations among Patients with Type 2 Diabetes. Am J Respir Crit Care Med. 2023 11 15; 208(10):1088-1100. PMID: 37647574; PMCID: PMC10867930.

A nasal cell atlas reveals heterogeneity of tuft cells and their role in directing olfactory stem cell proliferation

Ualiyeva S, Lemire E, Wong C, Perniss A, Boyd AA, Avilés EC, Minichetti DG, Maxfield A, Roditi R, Matsumoto I, Wang X, Deng W, Barrett NA, Buchheit KM, Laidlaw TM, Boyce JA, Bankova LG, Haber AL

TCF1-LEF1 co-expression identifies a multipotent progenitor cell (TH2-MPP) across human allergic diseases.

Kratchmarov R, Djeddi S, Dunlap G, He W, Jia X, Burk CM, Ryan T, McGill A, Allegretti JR, Kataru RP, Mehrara BJ, Taylor EM, Agarwal S, Bhattacharyya N, Bergmark RW, Maxfield AZ, Lee S, Roditi R, Dwyer DF, Boyce JA, Buchheit KM, Laidlaw TM, Shreffler WG, Rao DA, Gutierrez-Arcelus M, Brennan PJ

Mast cells control lung type 2 inflammation via prostaglandin E2-driven soluble ST2.

Alhallak K, Nagai J, Zaleski K, Marshall S, Salloum T, Derakhshan T, Hayashi H, Feng C, Kratchmarov R, Lai J, Kuchibhotla V, Nishida A, Balestrieri B, Laidlaw T, Dwyer DF, Boyce JA

IL-4Ra signaling promotes barrier-altering oncostatin M and IL-6 production in aspirin-exacerbated respiratory disease

Chen CC, Buchheit KM, Lee PY, Brodeur KE, Sohail A, Cho L, Baloh CH, Balestrieri B, Derakhshan T, Feng C, Boyce JA, Dwyer DF, Laidlaw TM

Rhinovirus infection of airway epithelial cells uncovers the non-ciliated subset as a likely driver of genetic risk to childhood-onset asthma

Djeddi S, Fernandez-Salinas D, Huang GX, Aguiar VRC, Mohanty C, Kendziorski C, Gazal S, Boyce JA, Ober C, Gern JE, Barrett NA, Gutierrez-Arcelus M

Human intraepithelial mast cell differentiation and effector function are directed by TGF-ß signaling

Derakhshan T, Hollers E, Perniss A, Ryan T, McGill A, Hacker J, Bergmark RW, Bhattacharyya N, Lee SE, Maxfield AZ, Roditi RE, Bankova L, Buchheit KM, Laidlaw TM, Boyce JA, Dwyer DF

Somatic hypermutation unlocks antibody specificities beyond the primary repertoire.

Zuo T, Gautam A, Saghaei S, Khobragade SN, Ahmed R, Mahdavinia A, Zarghami M, Pacheco GA, Green K, Travers M, Garcia N, Allahyari Z, Rao V, Kumar S, Novak R, Hwang JK, Wesemann DR

Select Publications

Immune recall improves antibody durability and breadth to SARS-CoV-2 variants

Yuezhou Chen, et al. Sci Immunol. 2022

Type 2 Inflammation Drives an Airway Basal Stem Cell Program Through Insulin Receptor Substrate Signaling

Xin Wang, et al. bioRixiv 2022

Comparative efficacy of tezepelumab to mepolizumab, benralizumab, and dupilumab in eosinophilic asthma: A Bayesian network meta-analysis

Ayobami Akenroye , et al. JACI 2022

Human airway mast cells proliferate and acquire distinct inflammation-driven phenotypes during type 2 inflammation

Daniel Dwyer, Sci Immunol. 2021

Maintaining Safety with SARS-CoV-2 Vaccines

Mariana Castells, New England Journal of Medicine 2021

Asthma Exacerbations in Patients with Type 2 Diabetes and Asthma on Glucagon-like Peptide-1 Receptor Agonists

Dinah Foer, Am J Respir Crit Care Med 2021

Quick COVID-19 Healers Sustain Anti-SARS-CoV-2 Antibody Production

Yuezhou Chen, Cell 2020

IL-5Rα marks nasal polyp IgG4- and IgE-expressing cells in AERD

Kathleen Buchheit, J Allergy Clin Immunol 2020

Airway brush cells generate cysteinyl leukotrienes through the ATP sensor P2Y2

Saltanat Ualiyeva, Sci Immunol. 2020

Seminar Series

Additional Information

For further Information please see links to our Research Faculty, Publications, Pre- and Post-doctoral Research Training Opportunities, and Allergy and Immunology Fellowship.