Contributing Author: Nora Barrett, M.D.

An adjuvant strategy enabled by modulation of the physical properties of microbial ligands expands antigen immunogenicity

Cell. 2022 Feb 2:S0092-8674(22)00067-8. doi: 10.1016/j.cell.2022.01.009. Online ahead of print. ABSTRACT Activation of the innate immune system via pattern recognition receptors (PRRs) is key to

Tuft cell-produced cysteinyl leukotrienes and IL-25 synergistically initiate lung type 2 inflammation

Sci Immunol. 2021 Dec 24;6(66):eabj0474. doi: 10.1126/sciimmunol.abj0474. Epub 2021 Dec 24. ABSTRACT [Figure: see text]. PMID:34932383 | DOI:10.1126/sciimmunol.abj0474

Evaluating the potential for respiratory metagenomics to improve treatment of secondary infection and detection of nosocomial transmission on expanded COVID-19 intensive care units

Genome Med. 2021 Nov 17;13(1):182. doi: 10.1186/s13073-021-00991-y. ABSTRACT BACKGROUND: Clinical metagenomics (CMg) has the potential to be translated from a research tool into routine service

Effect of Lower Tidal Volume Ventilation Facilitated by Extracorporeal Carbon Dioxide Removal vs Standard Care Ventilation on 90-Day Mortality in Patients With Acute Hypoxemic Respiratory Failure: The REST Randomized Clinical Trial

JAMA. 2021 Sep 21;326(11):1013-1023. doi: 10.1001/jama.2021.13374. ABSTRACT IMPORTANCE: In patients who require mechanical ventilation for acute hypoxemic respiratory failure, further reduction in tidal volumes, compared

Long-term cognitive and psychiatric outcomes of acute respiratory distress syndrome managed with Extracorporeal Membrane Oxygenation

Respir Med. 2021 Jul;183:106419. doi: 10.1016/j.rmed.2021.106419. Epub 2021 Apr 28. ABSTRACT BACKGROUND: Cognitive dysfunction is often reported in patients who have experienced acute respiratory distress

Human airway mast cells proliferate and acquire distinct inflammation-driven phenotypes during type 2 inflammation

Sci Immunol. 2021 Feb 26;6(56):eabb7221. doi: 10.1126/sciimmunol.abb7221. ABSTRACT Mast cells (MCs) play a pathobiologic role in type 2 (T2) allergic inflammatory diseases of the airway,

Identification of pathophysiological patterns for triage and respiratory support in COVID-19

Lancet Respir Med. 2020 Aug;8(8):752-754. doi: 10.1016/S2213-2600(20)30279-4. Epub 2020 Jun 26. NO ABSTRACT PMID:32598907 | PMC:PMC7319638 | DOI:10.1016/S2213-2600(20)30279-4

SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues

Cell. 2020 May 28;181(5):1016-1035.e19. doi: 10.1016/j.cell.2020.04.035. Epub 2020 Apr 27. ABSTRACT There is pressing urgency to understand the pathogenesis of the severe acute respiratory syndrome

Contributing Author: Nora Barrett, M.D.

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