KIT Inhibition by Imatinib in Patients with Severe Refractory Asthma
N Engl J Med. 2017 May 18;376(20):1911-1920. doi: 10.1056/NEJMoa1613125. ABSTRACT BACKGROUND: Mast cells are present in the airways of patients who have severe asthma despite
IL-4 acts on skin derived dendritic cells to promote the Th2 response to cutaneous sensitization and the development of allergic skin inflammation
J Allergy Clin Immunol. 2024 Jul 10:S0091-6749(24)00682-1. doi: 10.1016/j.jaci.2024.06.021. Online ahead of print. ABSTRACT BACKGROUND: Atopic dermatitis is characterized by scratching and a Th2-dominated local
Human airway mast cells proliferate and acquire distinct inflammation-driven phenotypes during type 2 inflammation
Sci Immunol. 2021 Feb 26;6(56):eabb7221. doi: 10.1126/sciimmunol.abb7221. ABSTRACT Mast cells (MCs) play a pathobiologic role in type 2 (T2) allergic inflammatory diseases of the airway,
Antibody Dynamics and Durability in Coronavirus Disease-19
Clin Lab Med. 2022 Mar;42(1):85-96. doi: 10.1016/j.cll.2021.10.004. Epub 2021 Nov 3. ABSTRACT Severe acute respiratory syndrome coronavirus 2 (COVID)-19 has emerged as the greatest global
Memory B cell repertoire for recognition of evolving SARS-CoV-2 spike
Cell. 2021 Sep 16;184(19):4969-4980.e15. doi: 10.1016/j.cell.2021.07.025. Epub 2021 Jul 23. ABSTRACT Memory B cell reserves can generate protective antibodies against repeated SARS-CoV-2 infections, but with
The CysLT2R receptor mediates leukotriene C4-driven acute and chronic itch
Proc Natl Acad Sci U S A. 2021 Mar 30;118(13):e2022087118. doi: 10.1073/pnas.2022087118. ABSTRACT Acute and chronic itch are burdensome manifestations of skin pathologies including allergic