Affinity Maturation and Light-Chain-Mediated Paratope Diversification Anticipate Viral Evolution
bioRxiv [Preprint]. 2025 Aug 28:2025.08.27.672735. doi: 10.1101/2025.08.27.672735. ABSTRACT A key goal of vaccinology is to train the immune system to combat current pathogens while simultaneously
Group V secretory phospholipase A2 modulates phagosome maturation and regulates the innate immune response against Candida albicans
J Immunol. 2009 Apr 15;182(8):4891-8. doi: 10.4049/jimmunol.0803776. ABSTRACT Phospholipase A(2) (PLA(2)) hydrolyzes the sn-2 position of cell membrane phospholipids to release fatty acids and lysophospholipids.
Dissecting strategies to tune the therapeutic potential of SARS-CoV-2-specific monoclonal antibody CR3022
JCI Insight. 2021 Jan 11;6(1):e143129. doi: 10.1172/jci.insight.143129. ABSTRACT The rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), coupled with a lack of therapeutics,
Antibodies induced by ancestral SARS-CoV-2 strain that cross-neutralize variants from Alpha to Omicron BA.1
Sci Immunol. 2022 May 10:eabo3425. doi: 10.1126/sciimmunol.abo3425. Online ahead of print. ABSTRACT Neutralizing antibodies that recognize the SARS-CoV-2 spike glycoprotein are the principal host defense
The cysteinyl leukotriene 3 receptor regulates expansion of IL-25-producing airway brush cells leading to type 2 inflammation
Sci Immunol. 2018 Oct 5;3(28):eaat9453. doi: 10.1126/sciimmunol.aat9453. ABSTRACT Respiratory epithelial cells (EpCs) orchestrate airway mucosal inflammation in response to diverse environmental stimuli, but how distinct
Expression and activation of the oxytocin receptor in airway smooth muscle cells: Regulation by TNFalpha and IL-13
Respir Res. 2010 Jul 29;11(1):104. doi: 10.1186/1465-9921-11-104. ABSTRACT BACKGROUND: During pregnancy asthma may remain stable, improve or worsen. The factors underlying the deleterious effect of