Human airway mast cells proliferate and acquire distinct inflammation-driven phenotypes during type 2 inflammation
Sci Immunol. 2021 Feb 26;6(56):eabb7221. doi: 10.1126/sciimmunol.abb7221. ABSTRACT Mast cells (MCs) play a pathobiologic role in type 2 (T2) allergic inflammatory diseases of the airway,
Group V secretory phospholipase A2 modulates phagosome maturation and regulates the innate immune response against Candida albicans
J Immunol. 2009 Apr 15;182(8):4891-8. doi: 10.4049/jimmunol.0803776. ABSTRACT Phospholipase A(2) (PLA(2)) hydrolyzes the sn-2 position of cell membrane phospholipids to release fatty acids and lysophospholipids.
Delayed Large Local Reactions to mRNA-1273 Vaccine against SARS-CoV-2
N Engl J Med. 2021 Apr 1;384(13):1273-1277. doi: 10.1056/NEJMc2102131. Epub 2021 Mar 3. NO ABSTRACT PMID:33657292 | PMC:PMC7944952 | DOI:10.1056/NEJMc2102131
Group V secretory phospholipase A2 is involved in macrophage activation and is sufficient for macrophage effector functions in allergic pulmonary inflammation
J Immunol. 2013 Jun 15;190(12):5927-38. doi: 10.4049/jimmunol.1203202. Epub 2013 May 6. ABSTRACT We reported that Pla2g5-null mice lacking group V secretory phospholipase A2 (gV-sPLA2) showed
SARS-CoV-2 infects the human kidney and drives fibrosis in kidney organoids
Cell Stem Cell. 2021 Dec 25:S1934-5909(21)00520-8. doi: 10.1016/j.stem.2021.12.010. Online ahead of print. ABSTRACT Kidney failure is frequently observed during and after COVID-19, but it remains
The cysteinyl leukotriene 3 receptor regulates expansion of IL-25-producing airway brush cells leading to type 2 inflammation
Sci Immunol. 2018 Oct 5;3(28):eaat9453. doi: 10.1126/sciimmunol.aat9453. ABSTRACT Respiratory epithelial cells (EpCs) orchestrate airway mucosal inflammation in response to diverse environmental stimuli, but how distinct