Sequential class switching generates antigen-specific gut IgA from IgG1 B cells
Immunity. 2025 Nov 17:S1074-7613(25)00476-5. doi: 10.1016/j.immuni.2025.10.022. Online ahead of print. ABSTRACT Immunoglobulin (Ig)A is the primary isotype protecting the gut barrier, yet fundamental aspects of
The CysLT2R receptor mediates leukotriene C4-driven acute and chronic itch
Proc Natl Acad Sci U S A. 2021 Mar 30;118(13):e2022087118. doi: 10.1073/pnas.2022087118. ABSTRACT Acute and chronic itch are burdensome manifestations of skin pathologies including allergic
Biological foundation models illuminate annotation blind spots in evolutionarily divergent genomes
bioRxiv [Preprint]. 2026 May 16:2026.05.15.724572. doi: 10.64898/2026.05.15.724572. ABSTRACT Chromosome-scale assemblies are increasingly available for non-model organisms, but functional annotation remains limited when deep evolutionary divergence
Human airway mast cells proliferate and acquire distinct inflammation-driven phenotypes during type 2 inflammation
Sci Immunol. 2021 Feb 26;6(56):eabb7221. doi: 10.1126/sciimmunol.abb7221. ABSTRACT Mast cells (MCs) play a pathobiologic role in type 2 (T2) allergic inflammatory diseases of the airway,
Effect of School Integrated Pest Management or Classroom Air Filter Purifiers on Asthma Symptoms in Students With Active Asthma: A Randomized Clinical Trial
JAMA. 2021 Sep 7;326(9):839-850. doi: 10.1001/jama.2021.11559. ABSTRACT IMPORTANCE: School and classroom allergens and particles are associated with asthma morbidity, but the benefit of environmental remediation
Association of Self-reported High-Risk Allergy History With Allergy Symptoms After COVID-19 Vaccination
JAMA Netw Open. 2021 Oct 1;4(10):e2131034. doi: 10.1001/jamanetworkopen.2021.31034. ABSTRACT IMPORTANCE: Allergic history in individuals with confirmed anaphylaxis to a messenger RNA (mRNA) COVID-19 vaccine is