Leukotriene E4 elicits respiratory epithelial cell mucin release through the G-protein-coupled receptor, GPR99
Proc Natl Acad Sci U S A. 2016 May 31;113(22):6242-7. doi: 10.1073/pnas.1605957113. Epub 2016 May 16. ABSTRACT Cysteinyl leukotrienes (cysLTs), leukotriene C4 (LTC4), LTD4, and
Group V secretory phospholipase A2 is involved in macrophage activation and is sufficient for macrophage effector functions in allergic pulmonary inflammation
J Immunol. 2013 Jun 15;190(12):5927-38. doi: 10.4049/jimmunol.1203202. Epub 2013 May 6. ABSTRACT We reported that Pla2g5-null mice lacking group V secretory phospholipase A2 (gV-sPLA2) showed
Structural and functional impact by SARS-CoV-2 Omicron spike mutations
Cell Rep. 2022 Apr 26;39(4):110729. doi: 10.1016/j.celrep.2022.110729. Epub 2022 Apr 11. ABSTRACT The Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), bearing an
Pharmacokinetic-pharmacodynamic modelling of the hypoglycaemic effect of pulsatile administration of human insulin in rats
Sci Rep. 2020 Nov 2;10(1):18876. doi: 10.1038/s41598-020-76007-3. ABSTRACT The relationship between the plasma insulin (INS) concentration-time course and plasma glucose concentration-time course during and after
SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues
Cell. 2020 May 28;181(5):1016-1035.e19. doi: 10.1016/j.cell.2020.04.035. Epub 2020 Apr 27. ABSTRACT There is pressing urgency to understand the pathogenesis of the severe acute respiratory syndrome
Affinity war: forging immunoglobulin repertoires
Curr Opin Immunol. 2019 Apr;57:32-39. doi: 10.1016/j.coi.2018.12.002. Epub 2019 Jan 25. ABSTRACT B cell immunoglobulin (Ig) repertoire composition shapes immune responses. The generation of Ig