Evaluating the potential for respiratory metagenomics to improve treatment of secondary infection and detection of nosocomial transmission on expanded COVID-19 intensive care units
Genome Med. 2021 Nov 17;13(1):182. doi: 10.1186/s13073-021-00991-y. ABSTRACT BACKGROUND: Clinical metagenomics (CMg) has the potential to be translated from a research tool into routine service
Effect of Lower Tidal Volume Ventilation Facilitated by Extracorporeal Carbon Dioxide Removal vs Standard Care Ventilation on 90-Day Mortality in Patients With Acute Hypoxemic Respiratory Failure: The REST Randomized Clinical Trial
JAMA. 2021 Sep 21;326(11):1013-1023. doi: 10.1001/jama.2021.13374. ABSTRACT IMPORTANCE: In patients who require mechanical ventilation for acute hypoxemic respiratory failure, further reduction in tidal volumes, compared
Mast Cells in Lung Damage of COVID-19 Autopsies: a descriptive study
Allergy. 2022 Mar 27. doi: 10.1111/all.15293. Online ahead of print. NO ABSTRACT PMID:35340030 | DOI:10.1111/all.15293
Tuft cell-produced cysteinyl leukotrienes and IL-25 synergistically initiate lung type 2 inflammation
Sci Immunol. 2021 Dec 24;6(66):eabj0474. doi: 10.1126/sciimmunol.abj0474. Epub 2021 Dec 24. ABSTRACT [Figure: see text]. PMID:34932383 | DOI:10.1126/sciimmunol.abj0474
Human airway mast cells proliferate and acquire distinct inflammation-driven phenotypes during type 2 inflammation
Sci Immunol. 2021 Feb 26;6(56):eabb7221. doi: 10.1126/sciimmunol.abb7221. ABSTRACT Mast cells (MCs) play a pathobiologic role in type 2 (T2) allergic inflammatory diseases of the airway,
Structural basis for enhanced infectivity and immune evasion of SARS-CoV-2 variants
Science. 2021 Aug 6;373(6555):642-648. doi: 10.1126/science.abi9745. Epub 2021 Jun 24. ABSTRACT Several fast-spreading variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have become the
