Heterogeneous bone-marrow stromal progenitors drive myelofibrosis via a druggable alarmin axis
Cell Stem Cell. 2021 Apr 1;28(4):637-652.e8. doi: 10.1016/j.stem.2020.11.004. Epub 2020 Dec 9. ABSTRACT Functional contributions of individual cellular components of the bone-marrow microenvironment to myelofibrosis
High-dimensional mapping of human CEACAM1 expression on immune cells and association with melanoma drug resistance
Commun Med (Lond). 2024 Jul 2;4(1):128. doi: 10.1038/s43856-024-00525-8. ABSTRACT BACKGROUND: Human carcinoembryonic antigen cell adhesion molecule 1 (CEACAM1) is an inhibitory cell surface protein that
How to Define and Manage Low-Risk Drug Allergy Labels
J Allergy Clin Immunol Pract. 2024 May;12(5):1095-1106. doi: 10.1016/j.jaip.2024.03.021. ABSTRACT Risk stratification in drug allergy implies that specific risk categories (eg, low, moderate, and high)
Transcriptional programs define molecular characteristics of innate lymphoid cell classes and subsets
Nat Immunol. 2015 Mar;16(3):306-17. doi: 10.1038/ni.3094. Epub 2015 Jan 26. ABSTRACT The recognized diversity of innate lymphoid cells (ILCs) is rapidly expanding. Three ILC classes
Multi-omic analysis reveals a key BCAT1 role in mTOR activation by B-cell receptor and TLR9
J Clin Invest. 2025 Sep 9:e186258. doi: 10.1172/JCI186258. Online ahead of print. ABSTRACT B-lymphocytes play major adaptive immune roles, producing antibody and driving T-cell responses.
Association of Self-reported High-Risk Allergy History With Allergy Symptoms After COVID-19 Vaccination
JAMA Netw Open. 2021 Oct 1;4(10):e2131034. doi: 10.1001/jamanetworkopen.2021.31034. ABSTRACT IMPORTANCE: Allergic history in individuals with confirmed anaphylaxis to a messenger RNA (mRNA) COVID-19 vaccine is