Pharmacological suppression of the kallikrein kinin system with KVD900: An orally available plasma kallikrein inhibitor for the on-demand treatment of hereditary angioedema
Clin Exp Allergy. 2022 Mar 12. doi: 10.1111/cea.14122. Online ahead of print. ABSTRACT BACKGROUND: Hereditary angioedema (HAE) is a rare genetic disease that leads to
Memory B cell repertoire for recognition of evolving SARS-CoV-2 spike
bioRxiv. 2021 Mar 10:2021.03.10.434840. doi: 10.1101/2021.03.10.434840. Preprint. ABSTRACT Memory B cell reserves can generate protective antibodies against repeated SARS-CoV-2 infections, but with an unknown reach
Rituximab Monotherapy for Common Variable Immune Deficiency-Associated Granulomatous-Lymphocytic Interstitial Lung Disease
Chest. 2019 May;155(5):e117-e121. doi: 10.1016/j.chest.2019.01.034. ABSTRACT Patients with common variable immunodeficiency (CVID) can develop granulomatous-lymphocytic interstitial lung disease (GLILD), which is associated with increased morbidity
Two distinct durable human class-switched memory B cell populations are induced by vaccination and infection
Cell Rep. 2025 Apr 1;44(4):115472. doi: 10.1016/j.celrep.2025.115472. Online ahead of print. ABSTRACT Memory lymphocytes are durable cells that persist in the absence of antigen, but
Group V secretory phospholipase A2 modulates phagosome maturation and regulates the innate immune response against Candida albicans
J Immunol. 2009 Apr 15;182(8):4891-8. doi: 10.4049/jimmunol.0803776. ABSTRACT Phospholipase A(2) (PLA(2)) hydrolyzes the sn-2 position of cell membrane phospholipids to release fatty acids and lysophospholipids.
COMPARATIVE EFFECTIVENESS OF OMALIZUMAB, MEPOLIZUMAB, AND DUPILUMAB IN ASTHMA: A TARGET TRIAL EMULATION
J Allergy Clin Immunol. 2023 Feb 3:S0091-6749(23)00144-6. doi: 10.1016/j.jaci.2023.01.020. Online ahead of print. ABSTRACT BACKGROUND: Multiple monoclonal antibodies are currently approved for the treatment of