Clonotype-enriched somatic hypermutations drive affinity maturation of a public human antibody targeting an occluded sarbecovirus epitope
Cell Rep. 2025 Aug 6:116122. doi: 10.1016/j.celrep.2025.116122. Online ahead of print. ABSTRACT Investigating public antibodies that recognize conserved epitopes is critical for vaccine development. Identifying
IL-4 and IL-13 form a negative feedback circuit with surfactant protein-D in the allergic airway response
J Immunol. 2006 Mar 15;176(6):3557-65. doi: 10.4049/jimmunol.176.6.3557. ABSTRACT The innate immune molecule surfactant protein-D (SP-D) plays an important regulatory role in the allergic airway response.
High-throughput, targeted MHC class I immunopeptidomics using a functional genetics screening platform
Nat Biotechnol. 2023 Jan 2. doi: 10.1038/s41587-022-01566-x. Online ahead of print. ABSTRACT Identification of CD8+ T cell epitopes is critical for the development of immunotherapeutics.
B cells regulate CD4+ T cell responses to papain following B cell receptor-independent papain uptake
J Immunol. 2014 Jul 15;193(2):529-39. doi: 10.4049/jimmunol.1303247. Epub 2014 Jun 13. ABSTRACT Papain, a cysteine protease allergen with inherent adjuvant activity, induces potent IL-4 expression
Identification of pathophysiological patterns for triage and respiratory support in COVID-19
Lancet Respir Med. 2020 Aug;8(8):752-754. doi: 10.1016/S2213-2600(20)30279-4. Epub 2020 Jun 26. NO ABSTRACT PMID:32598907 | PMC:PMC7319638 | DOI:10.1016/S2213-2600(20)30279-4
IL-4 acts on skin derived dendritic cells to promote the Th2 response to cutaneous sensitization and the development of allergic skin inflammation
J Allergy Clin Immunol. 2024 Jul 10:S0091-6749(24)00682-1. doi: 10.1016/j.jaci.2024.06.021. Online ahead of print. ABSTRACT BACKGROUND: Atopic dermatitis is characterized by scratching and a Th2-dominated local